Protein Details: voltage-gated potassium channel AKT2/3
Protein ID
ICDB_Pro_0919
Protein Name
voltage-gated potassium channel AKT2/3
Gene Name
AKT2; AKT3; At4g22200; T10I14.30
Organism
Arabidopsis thaliana (Mouse-ear cress)
Length
802 amino acids
AlphaFoldDB
AF-Q38898-F1-model_v4.pdb
Function
Highly selective and weak inward-rectifying potassium channel. Plays a role in both loading and unloading potassium into/from the phloem sap. Seems to control sugar loading into phloem via a voltage-dependent process. Blocked by physiological concentrations of external calcium and by external acidification. May interact with the cytoskeleton or with regulatory proteins. Dephosphorylation by PP2CA not only leads to the inhibition of potassium currents but also to an increase of the voltage-dependence of the channel. Regulated by the CBL4/CIPK6 calcium sensor/protein kinase complex via a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane
Sequence
PDB Structures
Ligand Binding
Binding Site
394..513
Disease
Location
Expressed mainly in the phloem tissues throughout the plant but also; at a lower level; in leaf epiderm; mesophyll and guard cells.
DOI ID
10.1104/pp.109.3.1093; 10.1016/0014-5793(95)01417-9; 10.1038/47134; 10.1111/tpj.13415; 10.1073/pnas.96.13.7581; 10.1007/s002329900476; 10.1105/tpc.12.6.837; 10.1093/jxb/52.354.181; 10.1104/pp.126.4.1646; 10.1007/s00425-002-0895-1; 10.1105/tpc.000943; 10.1105/tpc.003244; 10.1023/a:1022597102282; 10.1038/cr.2011.50; 10.1105/tpc.16.01050
RefSeq
NP_567651.1